The pharmaceutical industry has set itself the goal of increasing productivity in the production of antibiotics – while at the same time monitoring the quality of the drugs reliably and comprehensively. What was previously difficult to achieve using batch processes has now become possible by drawing on the wealth of experience and process expertise of BHS: Continuous processes offer great potential for increasing yield and improving quality assurance. Solid-liquid separation based on efficient, continuous filtration solutions is the key to achieving this.
Antibiotics have been saving lives worldwide in bacterially caused infectious diseases such as pneumonia or blood poisoning since the 1940s. The addition of this substance to the medical arsenal represents one of the most significant advances in medicine. And while its discovery was purely accidental, in modern production nothing is left to chance.
Filtration solutions from BHS guarantee excellent product purity, quality and process safety for antibiotics production. Continuous processes are increasingly replacing batch production. This allows manufacturers to achieve significantly higher product yields and greater throughput. Moreover, by combining these advantages with process analytical technology (PAT), measurable efficiency gains are achieved in the use of operating resources.
In antibiotics production, the active ingredient from the upstream reactor stage is usually present in crystalline form. This solid matter is separated and washed in one or more stages. The purified active ingredient is then mechanically dehumidified by blowing gas through it. The ingredient is then conveyed to the next process stage, which is usually thermal drying.